Little Flower High School was established in July 1953 by the Montfort Brothers of St. Gabriel, whose founder was the 17th century French priest and Catholic saint, Saint Louis de Montfort. The school was set up under the guidance of Rev. Bro. John of God, with Rev. Bro. Britto as its first Principal, to mark the centenary celebrations of All Saints High School, Hyderabad. Classes were started in temporary sheds from Kindergarten to Class VIII with two sections each. By 1957 there were classes till X with three sections each. The institution followed the HSLC course and later had the multi-purpose scheme from 1963 and came back to the SSC course.
LFHS was lauded as the best school in the twin cities and one of the ten best schools in India according to a survey conducted by the Outlook magazine (2001 - 2002 & 2002 - 2003) consecutively.Admissions to LKG are through a common admission procedure. Registration forms are usually issued by the third week of November. The vacancy list for classes I to IX will is displayed on the school notice board by the third week of April. The original birth certificate of the child has to be produced at the time of admission The school was rated as the country's second best school for excellence in computer education by the Government of India and the award was received by Rev. Bro. Franky Noronha from the then president Dr. A.P.J. Abdul Kalam in an official ceremony. The school has alumni like V. V. S. Laxman, Arshad Ayub, Speaker of the Andhra Pradesh Legislative Assembly, Suresh Reddy , Mithin Aachi,Dr. Mohd. Faheemuddin, Arvind Chenji, present Governor of Andhra Pradesh E.S.L. Narasimhan and Nandamuri Balakrishna.
In the academic year 2009-10, Outlook magazine ranked Little Flower High School as the best school in Hyderabad (Principal: Rev. Bro. Jaico Gervasis). In the same academic year, a student V Sri Krishna secured the first place in the scholarship test held by HDFC bank and won a scholarship worth Rs.10,00,000. In 2010, two students won the Horlicks Quiz competition and one was Runner Up in the TCS IT Quiz.
In 2006, two students namely Rithvik Ramadas and Abhinav Ram were a part of the team 'Space Architects' that were runners up in the International Space Settlement Design Competition held at Johnsons Space Center, Houston, Texas. Their team stood first in the Asian Finals of 2006. In 2010, a team of twelve students won the Asian finals again. They were teamed up with Amity International School, Saket and Lahore Grammar School Main,Lahore and was mentored by Abhinav Ram. Also in 2011, another team of twelve participated in the competition and were declared runners up. The school plans to take part in this competition again.
National rank : Ranked at No 75 position in the all-India rankings
State rank: Ranked at No 11 position in the state of Andhra Pradesh
City rank: Ranked at No 11 position in the city of Hyderabad